SERINC5 Restricts HIV-1 Infectivity by Promoting Conformational Changes and Accelerating Functional Inactivation of Env

SERINC5 incorporates into HIV-1 particles and inhibits the ability of Env glycoprotein to mediate virus-cell fusion. SERINC5-resistance maps to Env, with primary isolates generally showing greater resistance than laboratory-adapted strains. Here, we examined a relationship between the inhibition of...

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Detalles Bibliográficos
Autores principales: Kirschman, Junghwa, Marin, Mariana, Chen, Yen-Cheng, Chen, Junhua, Herschhorn, Alon, Smith, Amos B., Melikyan, Gregory B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323560/
https://www.ncbi.nlm.nih.gov/pubmed/35891369
http://dx.doi.org/10.3390/v14071388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323560/
https://www.ncbi.nlm.nih.gov/pubmed/35891369
http://dx.doi.org/10.3390/v14071388

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