Chloroquine-Induced DNA Damage Synergizes with Nonhomologous End Joining Inhibition to Cause Ovarian Cancer Cell Cytotoxicity

Ovarian cancer (OC) is the most lethal gynecological malignancy; therefore, more effective treatments are urgently needed. We recently reported that chloroquine (CQ) increased reactive oxygen species (ROS) in OC cell lines (OCCLs), causing DNA double-strand breaks (DSBs). Here, we analyzed whether t...

Descripción completa

Detalles Bibliográficos
Autores principales: Ovejero-Sánchez, María, Rubio-Heras, Jorge, Vicente de la Peña, María del Carmen, San-Segundo, Laura, Pérez-Losada, Jesús, González-Sarmiento, Rogelio, Herrero, Ana Belén
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323666/
https://www.ncbi.nlm.nih.gov/pubmed/35886866
http://dx.doi.org/10.3390/ijms23147518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323666/
https://www.ncbi.nlm.nih.gov/pubmed/35886866
http://dx.doi.org/10.3390/ijms23147518

Ejemplares similares