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Chloroquine-Induced DNA Damage Synergizes with Nonhomologous End Joining Inhibition to Cause Ovarian Cancer Cell Cytotoxicity

Ovarian cancer (OC) is the most lethal gynecological malignancy; therefore, more effective treatments are urgently needed. We recently reported that chloroquine (CQ) increased reactive oxygen species (ROS) in OC cell lines (OCCLs), causing DNA double-strand breaks (DSBs). Here, we analyzed whether t...

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Detalles Bibliográficos
Autores principales:	Ovejero-Sánchez, María, Rubio-Heras, Jorge, Vicente de la Peña, María del Carmen, San-Segundo, Laura, Pérez-Losada, Jesús, González-Sarmiento, Rogelio, Herrero, Ana Belén
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323666/ https://www.ncbi.nlm.nih.gov/pubmed/35886866 http://dx.doi.org/10.3390/ijms23147518

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