Synthesis and Evaluation of Small Molecule Drug Conjugates Harnessing Thioester-Linked Maytansinoids

Ligand-targeting drug conjugates are a class of clinically validated biopharmaceutical drugs constructed by conjugating cytotoxic drugs with specific disease antigen targeting ligands through appropriate linkers. The integrated linker-drug motif embedded within such a system can prevent the prematur...

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Detalles Bibliográficos
Autores principales: Lo, Chen-Fu, Chiu, Tai-Yu, Liu, Yu-Tzu, Huang, Li-Rung, Yeh, Teng-Kuang, Huang, Kuan-Hsun, Liu, Kuan-Liang, Hsu, Chia-Yu, Fang, Ming-Yu, Huang, Yu-Chen, Hsu, Tsu-An, Chen, Chiung-Tong, Tsou, Lun Kelvin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323955/
https://www.ncbi.nlm.nih.gov/pubmed/35890212
http://dx.doi.org/10.3390/pharmaceutics14071316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323955/
https://www.ncbi.nlm.nih.gov/pubmed/35890212
http://dx.doi.org/10.3390/pharmaceutics14071316

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