Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies

Human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms IX and XII are overexpressed in solid hypoxic tumors, and they are considered as prognostic tools and therapeutic targets for cancer. Based on a molecular simplification of the well-known coumarin scaffold, we developed a new series of derivatives...

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Detalles Bibliográficos
Autores principales: Pontecorvi, Virginia, Mori, Mattia, Picarazzi, Francesca, Zara, Susi, Carradori, Simone, Cataldi, Amelia, Angeli, Andrea, Berrino, Emanuela, Chimenti, Paola, Ciogli, Alessia, Secci, Daniela, Guglielmi, Paolo, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324074/
https://www.ncbi.nlm.nih.gov/pubmed/35887299
http://dx.doi.org/10.3390/ijms23147950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324074/
https://www.ncbi.nlm.nih.gov/pubmed/35887299
http://dx.doi.org/10.3390/ijms23147950

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