Identifying Structural Features of Nucleotide Analogues to Overcome SARS-CoV-2 Exonuclease Activity

With the recent global spread of new SARS-CoV-2 variants, there remains an urgent need to develop effective and variant-resistant oral drugs. Recently, we reported in vitro results validating the use of combination drugs targeting both the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and proofread...

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Detalles Bibliográficos
Autores principales: Wang, Xuanting, Tao, Chuanjuan, Morozova, Irina, Kalachikov, Sergey, Li, Xiaoxu, Kumar, Shiv, Russo, James J., Ju, Jingyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324094/
https://www.ncbi.nlm.nih.gov/pubmed/35891393
http://dx.doi.org/10.3390/v14071413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324094/
https://www.ncbi.nlm.nih.gov/pubmed/35891393
http://dx.doi.org/10.3390/v14071413

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