Cargando…

A Novel Late-Stage Autophagy Inhibitor That Efficiently Targets Lysosomes Inducing Potent Cytotoxic and Sensitizing Effects in Lung Cancer

SIMPLE SUMMARY: Lung cancer is the main cause of cancer-related deaths worldwide, mainly due to treatment resistance. For that reason, it is necessary to develop novel therapeutic strategies to overcome this phenomenon. The aim of our study was to design and characterize a synthetic anionophore, LAI...

Descripción completa

Detalles Bibliográficos
Autores principales:	Molero-Valenzuela, Adrià, Fontova, Pere, Alonso-Carrillo, Daniel, Carreira-Barral, Israel, Torres, Ana Aurora, García-Valverde, María, Benítez-García, Cristina, Pérez-Tomás, Ricardo, Quesada, Roberto, Soto-Cerrato, Vanessa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324127/ https://www.ncbi.nlm.nih.gov/pubmed/35884450 http://dx.doi.org/10.3390/cancers14143387

Ejemplares similares

Small molecule anion carriers facilitate lactate transport in model liposomes and cells
por: Alonso-Carrillo, Daniel, et al.
Publicado: (2023)

Antimetastatic Properties of Prodigiosin and the BH3-Mimetic Obatoclax (GX15-070) in Melanoma
por: Espona-Fiedler, Margarita, et al.
Publicado: (2022)

One-Pot Diastereoselective Synthesis of Pyrrolopiperazine-2,6-diones by a Ugi/Nucleophilic Substitution/N-Acylation Sequence
por: González-Saiz, Beatriz, et al.
Publicado: (2022)

Late Steps in Secretory Lysosome Exocytosis in Cytotoxic Lymphocytes
por: van der Sluijs, Peter, et al.
Publicado: (2013)

Multi-Smart and Scalable Bioligands-Free Nanomedical Platform for Intratumorally Targeted Tambjamine Delivery, a Difficult to Administrate Highly Cytotoxic Drug
por: Pérez-Hernández, Marta, et al.
Publicado: (2021)

Keto-Enol Tautomerism in Passerini and Ugi Adducts
por: Pertejo, Pablo, et al.
Publicado: (2021)

Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia
por: Gianotti, Ambra, et al.
Publicado: (2020)

The Natural-Based Antitumor Compound T21 Decreases Survivin Levels through Potent STAT3 Inhibition in Lung Cancer Models
por: Martínez-García, David, et al.
Publicado: (2019)

Steric hindrance, ligand ejection and associated photocytotoxic properties of ruthenium(II) polypyridyl complexes
por: Herrera-Ramírez, Piedad, et al.
Publicado: (2023)

Small molecule anionophores promote transmembrane anion permeation matching CFTR activity
por: Hernando, Elsa, et al.
Publicado: (2018)

Targeting Autophagy for Cancer Treatment and Tumor Chemosensitization
por: Pérez-Hernández, Marta, et al.
Publicado: (2019)

Democratization of Copper Analysis in Grape Must Following a Polymer-Based Lab-on-a-Chip Approach
por: Guirado-Moreno, José Carlos, et al.
Publicado: (2023)

Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content
por: Mundy, Dorothy I., et al.
Publicado: (2012)

ANTISERUM TO LEUCOCYTE LYSOSOMES : ITS CYTOTOXIC, GRANULOLYTIC, AND HEMOLYTIC ACTIVITIES
por: Quie, Paul G., et al.
Publicado: (1964)

Factors associated with patients’ and companions’ satisfaction with a hospital emergency department: A descriptive, cross‐sectional study
por: Fontova-Almató, Aurora, et al.
Publicado: (2019)

Oleandrin: A cardiac glycosides with potent cytotoxicity
por: Kumar, Arvind, et al.
Publicado: (2013)

Synthesis of Potent Cytotoxic Epidithiodiketopiperazines Designed for Derivatization
por: Olsson, Chase R., et al.
Publicado: (2020)

The Role of Intraorganellar Ca(2+)In Late Endosome–Lysosome Heterotypic Fusion and in the Reformation of Lysosomes from Hybrid Organelles
por: Pryor, Paul R., et al.
Publicado: (2000)

Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents
por: Jowett, Laura A., et al.
Publicado: (2017)

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes
Publicado: (1991)

The lysosomal enzyme receptor protein (LERP) is not essential, but is implicated in lysosomal function in Drosophila melanogaster
por: Hasanagic, Medina, et al.
Publicado: (2015)

Recruitment of dynein to late endosomes and lysosomes through light intermediate chains
por: Tan, Serena C., et al.
Publicado: (2011)

Potent cytotoxic effects of Calomeria amaranthoides on ovarian cancers
por: van Haaften, Caroline, et al.
Publicado: (2011)

Retraction: Oleandrin: A Cardiac Glycosides with Potent Cytotoxicity
Publicado: (2016)

NFBTA: A Potent Cytotoxic Agent against Glioblastoma
por: Turkez, Hasan, et al.
Publicado: (2019)

sp(2)-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
por: González-Cuesta, Manuel, et al.
Publicado: (2022)

Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A
por: Lu, Yingying, et al.
Publicado: (2014)

Pterostilbene-Induced Tumor Cytotoxicity: A Lysosomal Membrane Permeabilization-Dependent Mechanism
por: Mena, Salvador, et al.
Publicado: (2012)

Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells
por: Wiggins, Helen L., et al.
Publicado: (2015)

Role of Mitochondria and Lysosomes in the Selective Cytotoxicity of Cold Atmospheric Plasma on Retinoblastoma Cells
por: Tahmasebi, Ghazaleh, et al.
Publicado: (2020)

Potent Cytotoxic Arylnaphthalene Lignan Lactones from Phyllanthus poilanei
por: Ren, Yulin, et al.
Publicado: (2014)

Novel Terpenoids with Potent Cytotoxic Activities from Resina Commiphora
por: Hu, Bin-Yuan, et al.
Publicado: (2018)

Development of lysosome-mimicking vesicles to study the effect of abnormal accumulation of sphingosine on membrane properties
por: Carreira, Ana C., et al.
Publicado: (2017)

Rab11 is required for lysosome exocytosis through the interaction with Rab3a, Sec15 and GRAB
por: Escrevente, Cristina, et al.
Publicado: (2021)

Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse
por: Khazen, Roxana, et al.
Publicado: (2016)

Benzyl Isothiocyanate-Induced Cytotoxicity via the Inhibition of Autophagy and Lysosomal Function in AGS Cells
por: Po, Wah Wah, et al.
Publicado: (2022)

Lysosomes and Lysosomal Storage Diseases
por: Noebels, Jeffrey L.
Publicado: (1981)

Pdro, a Protein Associated with Late Endosomes and Lysosomes and Implicated in Cellular Cholesterol Homeostasis
por: Guillaumot, Patricia, et al.
Publicado: (2010)

Activation Mobilizes the Cholesterol in the Late Endosomes-Lysosomes of Niemann Pick Type C Cells
por: Lange, Yvonne, et al.
Publicado: (2012)

First-Generation Antipsychotic Haloperidol Alters the Functionality of the Late Endosomal/Lysosomal Compartment in Vitro
por: Canfrán-Duque, Alberto, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_aovmfhka0s9qnm53m6lalsjde0