Conformational Rearrangements Regulating the DNA Repair Protein APE1

Apurinic apyrimidinic endonuclease 1 (APE1) is a key enzyme of the Base Excision Repair (BER) pathway, which primarily manages oxidative lesions of DNA. Once the damaged base is removed, APE1 recognises the resulting abasic site and cleaves the phosphodiester backbone to allow for the correction by...

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Detalles Bibliográficos
Autores principales: Komaniecka, Nina, Porras, Marta, Cairn, Louis, Santas, Jon Ander, Ferreiro, Nerea, Penedo, Juan Carlos, Bañuelos, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324194/
https://www.ncbi.nlm.nih.gov/pubmed/35887361
http://dx.doi.org/10.3390/ijms23148015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324194/
https://www.ncbi.nlm.nih.gov/pubmed/35887361
http://dx.doi.org/10.3390/ijms23148015

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