Cargando…

Enlightening the “Spirit Molecule”: Photomodulation of the 5‐HT(2A) Receptor by a Light‐Controllable N,N‐Dimethyltryptamine Derivative

Classical psychedelics are a group of hallucinogens which trigger non‐ordinary states of consciousness through activation of the 5‐HT(2A) receptor (5‐HT(2A)R) in the brain. However, the exact mechanism of how 5‐HT(2A)R agonism alters perception remains elusive. When studying receptor signaling, tool...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gerwe, Hubert, He, Feng, Pottie, Eline, Stove, Christophe, Decker, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324199/ https://www.ncbi.nlm.nih.gov/pubmed/35349196 http://dx.doi.org/10.1002/anie.202203034

Ejemplares similares

Pharmacokinetics of N,N-dimethyltryptamine in Humans
por: Good, Meghan, et al.
Publicado: (2023)

N,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine
por: James, Edward, et al.
Publicado: (2022)

Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells
por: Szabo, Attila, et al.
Publicado: (2014)

Phenomenology and content of the inhaled N, N-dimethyltryptamine (N, N-DMT) experience
por: Lawrence, David Wyndham, et al.
Publicado: (2022)

Noncompetitive Inhibition of Indolethylamine-N-methyltransferase by N,N-Dimethyltryptamine and N,N-Dimethylaminopropyltryptamine
por: Chu, Uyen B., et al.
Publicado: (2014)

Reaction of N,N-Dimethyltryptamine with Dichloromethane Under Common Experimental Conditions
por: Dunlap, Lee E., et al.
Publicado: (2018)

Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain
por: Dean, Jon G., et al.
Publicado: (2019)

Indolethylamine-N-methyltransferase Polymorphisms: Genetic and Biochemical Approaches for Study of Endogenous N,N,-dimethyltryptamine
por: Dean, Jon G.
Publicado: (2018)

Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT
por: Barker, Steven A.
Publicado: (2022)

Photomodulation Approaches to Overcome Antimicrobial Resistance
por: Sarabando, Sofia N., et al.
Publicado: (2023)

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo
por: Morales-Garcia, Jose A., et al.
Publicado: (2020)

Population pharmacokinetic/pharmacodynamic modeling of the psychedelic experience induced by N,N‐dimethyltryptamine – Implications for dose considerations
por: Eckernäs, Emma, et al.
Publicado: (2022)

Photomodulation alleviates cellular senescence of aging adipose-derived stem cells
por: Zhang, Tao, et al.
Publicado: (2023)

Infoveillance and Critical Analysis of the Systematically Reviewed Literature on Dimethyltryptamine and the “God Molecule”
por: Al-Imam, Ahmed, et al.
Publicado: (2023)

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function
por: Barker, Steven A.
Publicado: (2018)

Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents
por: Cameron, Lindsay P., et al.
Publicado: (2019)

Detection and Quantification of Psychoactive N,N-Dimethyltryptamine in Ayahuasca Brews by Ambient Ionization High-Resolution Mass Spectrometry
por: Chambers, Megan I., et al.
Publicado: (2020)

Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact
por: Brito-da-Costa, Andreia Machado, et al.
Publicado: (2020)

The clinical pharmacology and potential therapeutic applications of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT)
por: Reckweg, Johannes T., et al.
Publicado: (2022)

N,N‐dimethyltryptamine affects electroencephalography response in a concentration‐dependent manner—A pharmacokinetic/pharmacodynamic analysis
por: Eckernäs, Emma, et al.
Publicado: (2023)

Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT(2A) Receptor Agonists
por: Poulie, Christian B. M., et al.
Publicado: (2022)

Photomodulation of G Protein-Coupled Adenosine Receptors by a Novel Light-Switchable Ligand
por: Bahamonde, María Isabel, et al.
Publicado: (2014)

The P2Y(2) Receptor C-Terminal Tail Modulates but Is Dispensable for β-Arrestin Recruitment
por: Pottie, Eline, et al.
Publicado: (2022)

High efficiency photomodulators for millimeter wave and THz radiation
por: Hooper, I. R., et al.
Publicado: (2019)

Acute Intoxication following Dimethyltryptamine Ingestion
por: Bilhimer, Matthew H., et al.
Publicado: (2018)

Optimized infusion rates for N,N‐dimethyltryptamine to achieve a target psychedelic intensity based on a modeling and simulation framework
por: Eckernäs, Emma, et al.
Publicado: (2023)

Photomodulating RNA cleavage using photolabile circular antisense oligodeoxynucleotides
por: Tang, XinJing, et al.
Publicado: (2010)

Fast Hollow Fiber Liquid-Phase Microextraction as a Greener Alternative for the Determination of N,N-Dimethyltryptamine and Harmala Alkaloids in Human Urine
por: Silveira, Gabriela de Oliveira, et al.
Publicado: (2020)

Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment
por: Uthaug, Malin V, et al.
Publicado: (2019)

Reactivations after 5-methoxy-N,N-dimethyltryptamine use in naturalistic settings: An initial exploratory analysis of the phenomenon’s predictors and its emotional valence
por: Ortiz Bernal, Ana María, et al.
Publicado: (2022)

Caged circular siRNAs for photomodulation of gene expression in cells and mice
por: Zhang, Liangliang, et al.
Publicado: (2017)

Photomodulation of bacterial growth and biofilm formation using carbohydrate-based surfactants
por: Hu, Yingxue, et al.
Publicado: (2016)

A study of photomodulated reflectance on staircase-like, n-doped GaAs/Al(x)Ga(1−x)As quantum well structures
por: Donmez, Omer, et al.
Publicado: (2012)

Structure–Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT(2A) Receptor Agonists
por: Pottie, Eline, et al.
Publicado: (2023)

Caged circular antisense oligonucleotides for photomodulation of RNA digestion and gene expression in cells
por: Wu, Li, et al.
Publicado: (2013)

Photomodulation of Transmembrane Transport and Potential by Stiff-Stilbene Based Bis(thio)ureas
por: Wezenberg, Sander J., et al.
Publicado: (2021)

Photomodulation in the treatment of chronic pain in patients with temporomandibular disorder: protocol for cost-effectiveness analysis
por: Sobral, Ana Paula Taboada, et al.
Publicado: (2018)

A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers
por: Reckweg, Johannes, et al.
Publicado: (2021)

A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N,N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers
por: Reckweg, J., et al.
Publicado: (2022)

A phase 1/2 trial to assess safety and efficacy of a vaporized 5-methoxy-N,N-dimethyltryptamine formulation (GH001) in patients with treatment-resistant depression
por: Reckweg, Johannes T., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fqh8si1ootuui8hg1pseisc1k7