Inhibitors of Deubiquitinating Enzymes Interfere with the SARS-CoV-2 Papain-like Protease and Block Virus Replication In Vitro

The ubiquitin proteasome system (UPS), particularly its deubiquitinating enzymes (DUBs), play a key role in the replication cycle of coronaviruses. The SARS-CoV-2 papain-like protease (Plpro) is known to process the viral polyproteins to form the replicase transcriptase complex and to counteract the...

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Detalles Bibliográficos
Autores principales: Große, Maximilian, Setz, Christian, Rauch, Pia, Auth, Janina, Morokutti-Kurz, Martina, Temchura, Vladimir, Schubert, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324251/
https://www.ncbi.nlm.nih.gov/pubmed/35891385
http://dx.doi.org/10.3390/v14071404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324251/
https://www.ncbi.nlm.nih.gov/pubmed/35891385
http://dx.doi.org/10.3390/v14071404

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