Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors

Allosteric HIV-1 integrase (IN) inhibitors, or ALLINIs, are a new class of antiviral agents that bind at the dimer interface of the IN, away from the enzymatic catalytic site and block viral replication by triggering an aberrant multimerization of the viral enzyme. To further our understanding of th...

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Detalles Bibliográficos
Autores principales: Dinh, Long Phi, Sun, Jian, Glenn, Courtney D., Patel, Krunal, Pigza, Julie A., Donahue, Matthew G., Yet, Larry, Kessl, Jacques J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324412/
https://www.ncbi.nlm.nih.gov/pubmed/35891446
http://dx.doi.org/10.3390/v14071466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324412/
https://www.ncbi.nlm.nih.gov/pubmed/35891446
http://dx.doi.org/10.3390/v14071466

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