Cargando…

Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors

Allosteric HIV-1 integrase (IN) inhibitors, or ALLINIs, are a new class of antiviral agents that bind at the dimer interface of the IN, away from the enzymatic catalytic site and block viral replication by triggering an aberrant multimerization of the viral enzyme. To further our understanding of th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dinh, Long Phi, Sun, Jian, Glenn, Courtney D., Patel, Krunal, Pigza, Julie A., Donahue, Matthew G., Yet, Larry, Kessl, Jacques J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324412/ https://www.ncbi.nlm.nih.gov/pubmed/35891446 http://dx.doi.org/10.3390/v14071466

Ejemplares similares

Optimized binding of substituted quinoline ALLINIs within the HIV-1 integrase oligomer
por: Sun, Jian, et al.
Publicado: (2021)

Quinolines from the cyclocondensation of isatoic anhydride with ethyl acetoacetate: preparation of ethyl 4-hydroxy-2-methylquinoline-3-carboxylate and derivatives
por: Jentsch, Nicholas G, et al.
Publicado: (2018)

HIV-1 Integrase-DNA Recognition Mechanisms
por: Kessl, Jacques J., et al.
Publicado: (2009)

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
por: Koneru, Pratibha C, et al.
Publicado: (2019)

The mechanism of H171T resistance reveals the importance of N(δ)-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase
por: Slaughter, Alison, et al.
Publicado: (2014)

Cis-Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase
por: Masuda, Takao, et al.
Publicado: (2022)

Scalable Preparation of the Masked Acyl Cyanide TBS-MAC
por: Hinton, Haley, et al.
Publicado: (2023)

Identification and Optimization of a Novel HIV-1 Integrase Inhibitor
por: Adu-Ampratwum, Daniel, et al.
Publicado: (2022)

Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase
por: Bonnard, Damien, et al.
Publicado: (2023)

A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase
por: Sharma, Amit, et al.
Publicado: (2014)

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence
por: Zhao, Xue Zhi, et al.
Publicado: (2018)

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage
por: Le Rouzic, Erwann, et al.
Publicado: (2013)

A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site
por: Maehigashi, Tatsuya, et al.
Publicado: (2021)

Integrase and integration: biochemical activities of HIV-1 integrase
por: Delelis, Olivier, et al.
Publicado: (2008)

Molecular Modeling Study on the Allosteric Inhibition Mechanism of HIV-1 Integrase by LEDGF/p75 Binding Site Inhibitors
por: Xue, Weiwei, et al.
Publicado: (2014)

Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors
por: Singh, Parmit Kumar, et al.
Publicado: (2022)

Rhodium-Promoted C–H Bond Activation of Quinoline, Methylquinolines, and Related Mono-Substituted Quinolines
por: de las Heras, Laura A., et al.
Publicado: (2022)

The Potential of 2-Substituted Quinolines as Antileishmanial Drug Candidates
por: Loiseau, Philippe M., et al.
Publicado: (2022)

Design, Practical Synthesis, and Biological Evaluation of Novel 6-(Pyrazolylmethyl)-4-quinoline-3-carboxylic Acid Derivatives as HIV-1 Integrase Inhibitors
por: Hu, Liming, et al.
Publicado: (2012)

HIV Protease and Integrase Empirical Substitution Models of Evolution: Protein-Specific Models Outperform Generalist Models
por: Del Amparo, Roberto, et al.
Publicado: (2021)

The Allosteric HIV-1 Integrase Inhibitor BI-D Affects Virion Maturation but Does Not Influence Packaging of a Functional RNA Genome
por: van Bel, Nikki, et al.
Publicado: (2014)

Relationship between HIV integrase polymorphisms and integrase inhibitor susceptibility: An in silico analysis
por: Hutapea, Hotma Martogi Lorensi, et al.
Publicado: (2018)

Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes
por: Bar-Magen, Tamara, et al.
Publicado: (2009)

The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity
por: Amadori, Céline, et al.
Publicado: (2017)

HIV-2 Integrase Variation in Integrase Inhibitor-Naïve Adults in Senegal, West Africa
por: Gottlieb, Geoffrey S., et al.
Publicado: (2011)

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis
por: Elliott, Jennifer L, et al.
Publicado: (2020)

Some Observations in the Use of Halogen Substituted Derivatives of Quinoline in Dermatological Practice
por: Chakravorty, A. N., et al.
Publicado: (1951)

Investigating the Spectrum of Biological Activity of Substituted Quinoline-2-Carboxamides and Their Isosteres (†)
por: Gonec, Tomas, et al.
Publicado: (2012)

Multimodal Functionalities of HIV-1 Integrase
por: Engelman, Alan N., et al.
Publicado: (2022)

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases
por: Zhao, Xue Zhi, et al.
Publicado: (2016)

HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants
por: Smith, Steven J., et al.
Publicado: (2021)

Characterization of natural polymorphic sites of the HIV-1 integrase before the introduction of HIV-1 integrase inhibitors in Germany
por: Meixenberger, Karolin, et al.
Publicado: (2014)

Nucleophilic Aromatic Substitution of Pentafluorophenyl-Substituted Quinoline with a Functional Perylene: A Route to the Modification of Semiconducting Polymers
por: Aivali, Stefania, et al.
Publicado: (2023)

Comparative biochemical analysis of wildtype and drug resistant HIV-1 integrase subtypes B and C
por: Bar-Magen, Tamara, et al.
Publicado: (2009)

Impact of the HIV integrase genetic context on the phenotypic expression and in vivo dynamics of integrase inhibitor resistance mutations
por: Nguyen, Nga, et al.
Publicado: (2013)

Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors
por: Meixenberger, Karolin, et al.
Publicado: (2017)

Pervasive Suicidal Integrases in Deep-Sea Archaea
por: Badel, Catherine, et al.
Publicado: (2020)

Raltegravir: first in class HIV integrase inhibitor
por: Temesgen, Zelalem, et al.
Publicado: (2008)

Patterns of resistance development with integrase inhibitors in HIV
por: Mbisa, Jean L, et al.
Publicado: (2011)

Novel therapeutic strategies targeting HIV integrase
por: Quashie, Peter K, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_cbn2vn7a1i8f1v05pm1asue23t