Compensatory Upregulation of LPA(2) and Activation of the PI3K-Akt Pathway Prevent LPA(5)-Dependent Loss of Intestinal Epithelial Cells in Intestinal Organoids

Renewal of the intestinal epithelium is orchestrated by regenerative epithelial proliferation within crypts. Recent studies have shown that lysophosphatidic acid (LPA) can maintain intestinal epithelial renewal in vitro and conditional deletion of Lpar5 (Lpar5(iKO)) in mice ablates the intestinal ep...

Descripción completa

Detalles Bibliográficos
Autores principales: Liang, Zhongxing, Yun, C. Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324510/
https://www.ncbi.nlm.nih.gov/pubmed/35883686
http://dx.doi.org/10.3390/cells11142243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324510/
https://www.ncbi.nlm.nih.gov/pubmed/35883686
http://dx.doi.org/10.3390/cells11142243

Ejemplares similares