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Compensatory Upregulation of LPA(2) and Activation of the PI3K-Akt Pathway Prevent LPA(5)-Dependent Loss of Intestinal Epithelial Cells in Intestinal Organoids
Renewal of the intestinal epithelium is orchestrated by regenerative epithelial proliferation within crypts. Recent studies have shown that lysophosphatidic acid (LPA) can maintain intestinal epithelial renewal in vitro and conditional deletion of Lpar5 (Lpar5(iKO)) in mice ablates the intestinal ep...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324510/ https://www.ncbi.nlm.nih.gov/pubmed/35883686 http://dx.doi.org/10.3390/cells11142243 |