A microRNA or messenger RNA point of departure estimates an apical endpoint point of departure in a rat developmental toxicity model

Traditional developmental toxicity testing practice examines fetal apical endpoints to identify a point of departure (POD) for risk assessment. A potential new testing paradigm involves deriving a POD from a comprehensive analysis of molecular‐level change. Here, the rat ketoconazole endocrine‐media...

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Detalles Bibliográficos
Autores principales: Johnson, Kamin J., Costa, Eduardo, Marshall, Valerie, Sriram, Shreedharan, Venkatraman, Anand, Stebbins, Kenneth, LaRocca, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324934/
https://www.ncbi.nlm.nih.gov/pubmed/35596682
http://dx.doi.org/10.1002/bdr2.2046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324934/
https://www.ncbi.nlm.nih.gov/pubmed/35596682
http://dx.doi.org/10.1002/bdr2.2046

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