Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action

In this study, we capitalized on our previously performed crystallographic fragment screen and developed the antitubulin small molecule Todalam with only two rounds of straightforward chemical synthesis. Todalam binds to a novel tubulin site, disrupts microtubule networks in cells, arrests cells in...

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Detalles Bibliográficos
Autores principales: Mühlethaler, Tobias, Milanos, Lampros, Ortega, Jose Antonio, Blum, Thorsten B., Gioia, Dario, Roy, Bibhas, Prota, Andrea E., Cavalli, Andrea, Steinmetz, Michel O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324959/
https://www.ncbi.nlm.nih.gov/pubmed/35404502
http://dx.doi.org/10.1002/anie.202204052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324959/
https://www.ncbi.nlm.nih.gov/pubmed/35404502
http://dx.doi.org/10.1002/anie.202204052

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