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An overview of mutational and copy number signatures in human cancer

The genome of each cell in the human body is constantly under assault from a plethora of exogenous and endogenous processes that can damage DNA. If not successfully repaired, DNA damage generally becomes permanently imprinted in cells, and all their progenies, as somatic mutations. In most cases, th...

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Detalles Bibliográficos
Autores principales: Steele, Christopher D, Pillay, Nischalan, Alexandrov, Ludmil B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324981/
https://www.ncbi.nlm.nih.gov/pubmed/35420163
http://dx.doi.org/10.1002/path.5912