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Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms
For decades, vaccines have played a significant role in protecting public and personal health against infectious diseases and proved their great potential in battling cancers as well. This review focused on the current progress of therapeutic subunit vaccines for cancer immunotherapy. Antigens and a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325128/ https://www.ncbi.nlm.nih.gov/pubmed/35890342 http://dx.doi.org/10.3390/pharmaceutics14071448 |
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author | Alarcon, Neftali Ortega Jaramillo, Maddy Mansour, Heidi M. Sun, Bo |
author_facet | Alarcon, Neftali Ortega Jaramillo, Maddy Mansour, Heidi M. Sun, Bo |
author_sort | Alarcon, Neftali Ortega |
collection | PubMed |
description | For decades, vaccines have played a significant role in protecting public and personal health against infectious diseases and proved their great potential in battling cancers as well. This review focused on the current progress of therapeutic subunit vaccines for cancer immunotherapy. Antigens and adjuvants are key components of vaccine formulations. We summarized several classes of tumor antigens and bioinformatic approaches of identification of tumor neoantigens. Pattern recognition receptor (PRR)-targeting adjuvants and their targeted delivery platforms have been extensively discussed. In addition, we emphasized the interplay between multiple adjuvants and their combined delivery for cancer immunotherapy. |
format | Online Article Text |
id | pubmed-9325128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93251282022-07-27 Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms Alarcon, Neftali Ortega Jaramillo, Maddy Mansour, Heidi M. Sun, Bo Pharmaceutics Review For decades, vaccines have played a significant role in protecting public and personal health against infectious diseases and proved their great potential in battling cancers as well. This review focused on the current progress of therapeutic subunit vaccines for cancer immunotherapy. Antigens and adjuvants are key components of vaccine formulations. We summarized several classes of tumor antigens and bioinformatic approaches of identification of tumor neoantigens. Pattern recognition receptor (PRR)-targeting adjuvants and their targeted delivery platforms have been extensively discussed. In addition, we emphasized the interplay between multiple adjuvants and their combined delivery for cancer immunotherapy. MDPI 2022-07-11 /pmc/articles/PMC9325128/ /pubmed/35890342 http://dx.doi.org/10.3390/pharmaceutics14071448 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Alarcon, Neftali Ortega Jaramillo, Maddy Mansour, Heidi M. Sun, Bo Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms |
title | Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms |
title_full | Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms |
title_fullStr | Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms |
title_full_unstemmed | Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms |
title_short | Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms |
title_sort | therapeutic cancer vaccines—antigen discovery and adjuvant delivery platforms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325128/ https://www.ncbi.nlm.nih.gov/pubmed/35890342 http://dx.doi.org/10.3390/pharmaceutics14071448 |
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