Comparative Characterization of Different Molecular Formats of Bispecific Antibodies Targeting EGFR and PD-L1

We generated two IgG1-like bispecific antibodies (BsAbs) with different molecular formats, symmetrical DVD-Ig and asymmetrical knob-in-hole (KIH), targeting the same antigens, EGFR and PD-L1 (designated as anti-EGFR/PD-L1). We performed the physiochemical and biological characterization of these two...

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Detalles Bibliográficos
Autores principales: Mohan, Nishant, Agrawal, Atul, Shen, Yi, Winarski, Katie L., Endo, Yukinori, Dokmanovic, Milos, Schmiel, Deborah, Zheng, Jiwen, Rotstein, David S., Pelosof, Lorraine C., Wu, Wen Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325241/
https://www.ncbi.nlm.nih.gov/pubmed/35890277
http://dx.doi.org/10.3390/pharmaceutics14071381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325241/
https://www.ncbi.nlm.nih.gov/pubmed/35890277
http://dx.doi.org/10.3390/pharmaceutics14071381

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