Children with atopic dermatitis show increased activity of β‐glucocerebrosidase and stratum corneum levels of glucosylcholesterol that are strongly related to the local cytokine milieu

BACKGROUND: Atopic dermatitis (AD) is characterized by immune dysregulations and an impaired skin barrier, including abnormalities in lipid organization. In the stratum corneum (SC), β‐glucocerebrosidase (GBA) mediates transformation of glucosylceramide (GlcCER) into ceramide (CER) and cholesterol i...

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Detalles Bibliográficos
Autores principales: Kezic, Sanja, McAleer, Maeve A., Jakasa, Ivone, Goorden, Susan M.I., der Vlugt, Karen Ghauharali‐van, Beers‐Stet, Femke S., Meijer, Judith, Roelofsen, Jeroen, Nieman, Monique M., van Kuilenburg, André B.P., Irvine, Alan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325351/
https://www.ncbi.nlm.nih.gov/pubmed/34993951
http://dx.doi.org/10.1111/bjd.20979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325351/
https://www.ncbi.nlm.nih.gov/pubmed/34993951
http://dx.doi.org/10.1111/bjd.20979

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