Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2,4‐Substituted Quinazoline Derivatives

Some 2,4‐disubstituted quinazolines were synthesized and studied as multidrug resistance (MDR) reversers. The new derivatives carried the quinazoline‐4‐amine scaffold found in modulators of the ABC transporters involved in MDR, as the TKIs gefitinib and erlotinib. Their behaviour on the three ABC tr...

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Detalles Bibliográficos
Autores principales: Braconi, Laura, Teodori, Elisabetta, Contino, Marialessandra, Riganti, Chiara, Bartolucci, Gianluca, Manetti, Dina, Romanelli, Maria Novella, Perrone, Maria Grazia, Colabufo, Nicola Antonio, Guglielmo, Stefano, Dei, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325490/
https://www.ncbi.nlm.nih.gov/pubmed/35416421
http://dx.doi.org/10.1002/cmdc.202200027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325490/
https://www.ncbi.nlm.nih.gov/pubmed/35416421
http://dx.doi.org/10.1002/cmdc.202200027

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