Cargando…

Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2,4‐Substituted Quinazoline Derivatives

Some 2,4‐disubstituted quinazolines were synthesized and studied as multidrug resistance (MDR) reversers. The new derivatives carried the quinazoline‐4‐amine scaffold found in modulators of the ABC transporters involved in MDR, as the TKIs gefitinib and erlotinib. Their behaviour on the three ABC tr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Braconi, Laura, Teodori, Elisabetta, Contino, Marialessandra, Riganti, Chiara, Bartolucci, Gianluca, Manetti, Dina, Romanelli, Maria Novella, Perrone, Maria Grazia, Colabufo, Nicola Antonio, Guglielmo, Stefano, Dei, Silvia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325490/ https://www.ncbi.nlm.nih.gov/pubmed/35416421 http://dx.doi.org/10.1002/cmdc.202200027

Ejemplares similares

6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers
por: Braconi, Laura, et al.
Publicado: (2020)

New Dual P-Glycoprotein (P-gp) and Human Carbonic Anhydrase XII (hCA XII) Inhibitors as Multidrug Resistance (MDR) Reversers in Cancer Cells
por: Braconi, Laura, et al.
Publicado: (2022)

Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells †
por: Teodori, Elisabetta, et al.
Publicado: (2020)

Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators
por: Dei, Silvia, et al.
Publicado: (2019)

Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators
por: Manetti, Dina, et al.
Publicado: (2023)

New Strategies to Overcome Resistance to Chemotherapy and Immune System in Cancer
por: Riganti, Chiara, et al.
Publicado: (2019)

Small and Innovative Molecules as New Strategy to Revert MDR
por: Zinzi, Laura, et al.
Publicado: (2014)

Receptor-Drug Interaction: Europium Employment for Studying the Biochemical Pathway of G-Protein-Coupled Receptor Activation
por: Antonio, Colabufo Nicola, et al.
Publicado: (2007)

New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators
por: Chiaramonte, Niccolò, et al.
Publicado: (2022)

Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine(1)
por: Chiaramonte, Niccolò, et al.
Publicado: (2020)

The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line
por: Pagliarulo, Vincenzo, et al.
Publicado: (2013)

Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death
por: Kopecka, Joanna, et al.
Publicado: (2020)

Why PB28 Could Be a Covid 2019 Game Changer?
por: Colabufo, Nicola Antonio, et al.
Publicado: (2020)

miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives
por: Gisel, Andreas, et al.
Publicado: (2014)

Editorial: The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation
por: Contino, Marialessandra, et al.
Publicado: (2017)

Simultaneous Degradation Study of Isomers in Human Plasma by HPLC-MS/MS and Application of LEDA Algorithm for Their Characterization
por: Pallecchi, Marco, et al.
Publicado: (2022)

Isomers Recognition in HPLC-MS/MS Analysis of Human Plasma Samples by Using an Ion Trap Supported by a Linear Equations-Based Algorithm
por: Pallecchi, Marco, et al.
Publicado: (2023)

An innovative small molecule for promoting neuroreparative strategies
por: Colabufo, Nicola Antonio, et al.
Publicado: (2018)

ABC transporters in CSCs membranes as a novel target for treating tumor relapse
por: Zinzi, Laura, et al.
Publicado: (2014)

Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents
por: Feng, Senling, et al.
Publicado: (2020)

PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships
por: Abate, Carmen, et al.
Publicado: (2020)

Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators
por: Angeli, Andrea, et al.
Publicado: (2017)

Amino Acids as Building Blocks for Carbonic Anhydrase Inhibitors
por: Chiaramonte, Niccolò, et al.
Publicado: (2018)

Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine
por: Gualdani, Roberta, et al.
Publicado: (2015)

Intracellular targeted co-delivery of shMDR1 and gefitinib with chitosan nanoparticles for overcoming multidrug resistance
por: Yu, Xiwei, et al.
Publicado: (2015)

MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor
por: Riganti, Chiara, et al.
Publicado: (2020)

The multiple combination of Paclitaxel, Ramucirumab and Elacridar reverses the paclitaxel-mediated resistance in gastric cancer cell lines
por: Schirizzi, Annalisa, et al.
Publicado: (2023)

HCN Channels Modulators: The Need for Selectivity
por: Romanelli, Maria Novella, et al.
Publicado: (2016)

Comparison of characteristics and mortality in multidrug resistant (MDR) and non-MDR tuberculosis patients in China
por: Sun, Yanni, et al.
Publicado: (2015)

The effect of varying multidrug-resistence (MDR) definitions on rates of MDR gram-negative rods
por: Wolfensberger, Aline, et al.
Publicado: (2019)

Multidrug resistance (mdr) genes in human cancer.
por: Nooter, K., et al.
Publicado: (1991)

Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies
por: Catalano, Alessia, et al.
Publicado: (2022)

Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain
por: Contino, Marialessandra, et al.
Publicado: (2020)

Editorial: Molecular modulators of GPCRs signal transduction
por: Vrecl, Milka, et al.
Publicado: (2023)

Prevention of multidrug resistance (MDR) in osteosarcoma by NSC23925
por: Yang, X, et al.
Publicado: (2014)

Predictors of Multidrug-Resistant Tuberculosis (MDR-TB) in Sudan
por: Ali, Monadil H., et al.
Publicado: (2019)

Epoxylathyrane Derivatives as MDR-Selective Compounds for Disabling Multidrug Resistance in Cancer
por: Reis, Mariana Alves, et al.
Publicado: (2020)

Collaborative public–private initiatives targeting multidrug-resistant tuberculosis (MDR-TB) supported by the Lilly MDR-TB Partnership: experiences in 2012–2016
por: Shelby, Peter W, et al.
Publicado: (2017)

Regulation and expression of multidrug resistance (MDR) transcripts in the intestinal epithelium
por: Li, M, et al.
Publicado: (1999)

Novel strategies to prevent the development of multidrug resistance (MDR) in cancer
por: Wang, Jinglu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_j6j4rhu60ju86112drfm41ve38