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Oxidative stress differentially impacts apical and basolateral secretion of angiogenic factors from human iPSC-derived retinal pigment epithelium cells

The retinal pigment epithelium (RPE) is a polarized monolayer that secretes growth factors and cytokines towards the retina apically and the choroid basolaterally. Numerous RPE secreted proteins have been linked to the pathogenesis of age-related macular degeneration (AMD). The purpose of this study...

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Detalles Bibliográficos
Autores principales: Chen, Lisheng, Perera, N. Dayanthi, Karoukis, Athanasios J., Feathers, Kecia L., Ali, Robin R., Thompson, Debra A., Fahim, Abigail T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325713/
https://www.ncbi.nlm.nih.gov/pubmed/35882889
http://dx.doi.org/10.1038/s41598-022-16701-6