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Oxidative stress differentially impacts apical and basolateral secretion of angiogenic factors from human iPSC-derived retinal pigment epithelium cells

The retinal pigment epithelium (RPE) is a polarized monolayer that secretes growth factors and cytokines towards the retina apically and the choroid basolaterally. Numerous RPE secreted proteins have been linked to the pathogenesis of age-related macular degeneration (AMD). The purpose of this study...

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Detalles Bibliográficos
Autores principales:	Chen, Lisheng, Perera, N. Dayanthi, Karoukis, Athanasios J., Feathers, Kecia L., Ali, Robin R., Thompson, Debra A., Fahim, Abigail T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325713/ https://www.ncbi.nlm.nih.gov/pubmed/35882889 http://dx.doi.org/10.1038/s41598-022-16701-6

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