Biocatalytic decarboxylative Michael addition for synthesis of 1,4-benzoxazinone derivatives

The Candida antarctica lipase B (Novozym 435) is found to catalyze a novel decarboxylative Michael addition in vinylogous carbamate systems for the synthesis of 1,4-benzoxazinone derivatives. The reaction goes through Michael addition, ester hydrolysis and decarboxylation. A possible mechanism is su...

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Detalles Bibliográficos
Autores principales: Bavandi, Hossein, Shahedi, Mansour, Habibi, Zohreh, Yousefi, Maryam, Brask, Jesper, Mohammadi, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325775/
https://www.ncbi.nlm.nih.gov/pubmed/35882869
http://dx.doi.org/10.1038/s41598-022-16291-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325775/
https://www.ncbi.nlm.nih.gov/pubmed/35882869
http://dx.doi.org/10.1038/s41598-022-16291-3

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