Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis

Drugs are often withdrawn from the market due to the manifestation of drug-induced liver injury (DILI) in patients. Drug-induced cholestasis (DIC), defined as obstruction of hepatic bile flow due to medication, is one form of DILI. Because DILI is idiosyncratic, and the resulting cholestasis complex...

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Detalles Bibliográficos
Autores principales: Karsten, R. E. H., Krijnen, N. J. W., Maho, W., Permentier, H., Verpoorte, E., Olinga, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
In Vitro Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325861/
https://www.ncbi.nlm.nih.gov/pubmed/35708773
http://dx.doi.org/10.1007/s00204-022-03321-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325861/
https://www.ncbi.nlm.nih.gov/pubmed/35708773
http://dx.doi.org/10.1007/s00204-022-03321-2

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