Multi-mtDNA Variants May Be a Factor Contributing to Mitochondrial Function Variety in the Skin-Derived Fibroblasts of Leber's Hereditary Optic Neuropathy Patients

Heterogeneity is a major feature of Leber's hereditary optic neuropathy (LHON) and has a significant impact on the manifestation and diagnosis of the disease. This study explored whether multiple variations in mitochondrial genes were associated with the heterogeneity, mainly phenotypic heterog...

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Detalles Bibliográficos
Autores principales: Yao, Shun, Zhou, Qingru, Yang, Mingzhu, Li, Ya, Jin, Xiuxiu, Guo, Qingge, Yang, Lin, Qin, Fangyuan, Lei, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326446/
https://www.ncbi.nlm.nih.gov/pubmed/35909448
http://dx.doi.org/10.3389/fnmol.2022.920221

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