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Effects of processing adjuvants on traditional Chinese herbs

Processing of Chinese medicines is a pharmaceutical technique that transforms medicinal raw materials into decoction pieces for use in different therapies. Various adjuvants, such as vinegar, wine, honey, and brine, are used in the processing to enhance the efficacy and reduce the toxicity of crude...

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Autores principales: Chen, Lin-Lin, Verpoorte, Robert, Yen, Hung-Rong, Peng, Wen-Huang, Cheng, Yung-Chi, Chao, Jung, Pao, Li-Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326876/
https://www.ncbi.nlm.nih.gov/pubmed/29703391
http://dx.doi.org/10.1016/j.jfda.2018.02.004
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author Chen, Lin-Lin
Verpoorte, Robert
Yen, Hung-Rong
Peng, Wen-Huang
Cheng, Yung-Chi
Chao, Jung
Pao, Li-Heng
author_facet Chen, Lin-Lin
Verpoorte, Robert
Yen, Hung-Rong
Peng, Wen-Huang
Cheng, Yung-Chi
Chao, Jung
Pao, Li-Heng
author_sort Chen, Lin-Lin
collection PubMed
description Processing of Chinese medicines is a pharmaceutical technique that transforms medicinal raw materials into decoction pieces for use in different therapies. Various adjuvants, such as vinegar, wine, honey, and brine, are used in the processing to enhance the efficacy and reduce the toxicity of crude drugs. Proper processing is essential to ensure the quality and safety of traditional Chinese medicines (TCMs). Therefore, sound knowledge of processing principles is crucial to the standardized use of these processing adjuvants and to facilitate the production and clinical use of decoction pieces. Many scientific reports have indicated the synergistic effects of processing mechanisms on the chemistry, pharmacology, and pharmacokinetics of the active ingredients in TCMs. Under certain conditions, adjuvants change the content of active or toxic components in drugs by chemical or physical transformation, increase or decrease drug dissolution, exert their own pharmacological effects, or alter drug pharmacokinetics. This review summarizes various processing methods adopted in the last two decades, and highlights current approaches to identify the effects of processing parameters on TCMs.
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spelling pubmed-93268762022-08-09 Effects of processing adjuvants on traditional Chinese herbs Chen, Lin-Lin Verpoorte, Robert Yen, Hung-Rong Peng, Wen-Huang Cheng, Yung-Chi Chao, Jung Pao, Li-Heng J Food Drug Anal Review Article Processing of Chinese medicines is a pharmaceutical technique that transforms medicinal raw materials into decoction pieces for use in different therapies. Various adjuvants, such as vinegar, wine, honey, and brine, are used in the processing to enhance the efficacy and reduce the toxicity of crude drugs. Proper processing is essential to ensure the quality and safety of traditional Chinese medicines (TCMs). Therefore, sound knowledge of processing principles is crucial to the standardized use of these processing adjuvants and to facilitate the production and clinical use of decoction pieces. Many scientific reports have indicated the synergistic effects of processing mechanisms on the chemistry, pharmacology, and pharmacokinetics of the active ingredients in TCMs. Under certain conditions, adjuvants change the content of active or toxic components in drugs by chemical or physical transformation, increase or decrease drug dissolution, exert their own pharmacological effects, or alter drug pharmacokinetics. This review summarizes various processing methods adopted in the last two decades, and highlights current approaches to identify the effects of processing parameters on TCMs. Taiwan Food and Drug Administration 2018-03-19 /pmc/articles/PMC9326876/ /pubmed/29703391 http://dx.doi.org/10.1016/j.jfda.2018.02.004 Text en © 2018 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Review Article
Chen, Lin-Lin
Verpoorte, Robert
Yen, Hung-Rong
Peng, Wen-Huang
Cheng, Yung-Chi
Chao, Jung
Pao, Li-Heng
Effects of processing adjuvants on traditional Chinese herbs
title Effects of processing adjuvants on traditional Chinese herbs
title_full Effects of processing adjuvants on traditional Chinese herbs
title_fullStr Effects of processing adjuvants on traditional Chinese herbs
title_full_unstemmed Effects of processing adjuvants on traditional Chinese herbs
title_short Effects of processing adjuvants on traditional Chinese herbs
title_sort effects of processing adjuvants on traditional chinese herbs
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326876/
https://www.ncbi.nlm.nih.gov/pubmed/29703391
http://dx.doi.org/10.1016/j.jfda.2018.02.004
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