Transporter-mediated interaction of indican and methotrexate in rats

Indican (indoxyl-β-D-glucoside) is present in several Chinese herbs e.g. Isatis indigotica, Polygonum tinctorium and Polygonum perfoliatum. The major metabolite of indican was indoxyl sulfate (IS), an uremic toxin which was a known substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and...

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Detalles Bibliográficos
Autores principales: Lin, Shiuan-Pey, Yu, Chung-Ping, Hou, Yu-Chi, Huang, Ching-Ya, Ho, Lu-Ching, Chan, Shu-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326885/
https://www.ncbi.nlm.nih.gov/pubmed/29703382
http://dx.doi.org/10.1016/j.jfda.2017.11.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326885/
https://www.ncbi.nlm.nih.gov/pubmed/29703382
http://dx.doi.org/10.1016/j.jfda.2017.11.006

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