Activation of Glycyl Radical Enzymes—Multiscale Modeling Insights into Catalysis and Radical Control in a Pyruvate Formate-Lyase-Activating Enzyme

[Image: see text] Pyruvate formate-lyase (PFL) is a glycyl radical enzyme (GRE) playing a pivotal role in the metabolism of strict and facultative anaerobes. Its activation is carried out by a PFL-activating enzyme, a member of the radical S-adenosylmethionine (rSAM) superfamily of metalloenzymes, w...

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Detalles Bibliográficos
Autores principales: Hanževački, Marko, Croft, Anna K., Jäger, Christof M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326890/
https://www.ncbi.nlm.nih.gov/pubmed/35771966
http://dx.doi.org/10.1021/acs.jcim.2c00362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326890/
https://www.ncbi.nlm.nih.gov/pubmed/35771966
http://dx.doi.org/10.1021/acs.jcim.2c00362

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