Click-Chemistry-Based Biomimetic Ligands Efficiently Capture G-Quadruplexes In Vitro and Help Localize Them at DNA Damage Sites in Human Cells

[Image: see text] Interrogating G-quadruplex (G4) biology at its deepest roots in human cells relies on the design, synthesis, and use of ever smarter molecular tools. Here, we demonstrate the versatility of biomimetic G4 ligands referred to as TASQ (template assembled synthetic G-quartet) in which...

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Detalles Bibliográficos
Autores principales: Rota Sperti, Francesco, Dupouy, Baptiste, Mitteaux, Jérémie, Pipier, Angélique, Pirrotta, Marc, Chéron, Nicolas, Valverde, Ibai E., Monchaud, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327089/
https://www.ncbi.nlm.nih.gov/pubmed/35911444
http://dx.doi.org/10.1021/jacsau.2c00082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327089/
https://www.ncbi.nlm.nih.gov/pubmed/35911444
http://dx.doi.org/10.1021/jacsau.2c00082

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