Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy

TDP-43 mediates proper Stathmin-2 (STMN2) mRNA splicing, and STMN2 protein is reduced in the spinal cord of most patients with amyotrophic lateral sclerosis (ALS). To test the hypothesis that STMN2 loss contributes to ALS pathogenesis, we generated constitutive and conditional STMN2 knockout mice. C...

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Detalles Bibliográficos
Autores principales: Krus, Kelsey L., Strickland, Amy, Yamada, Yurie, Devault, Laura, Schmidt, Robert E., Bloom, A. Joseph, Milbrandt, Jeffrey, DiAntonio, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327139/
https://www.ncbi.nlm.nih.gov/pubmed/35767949
http://dx.doi.org/10.1016/j.celrep.2022.111001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327139/
https://www.ncbi.nlm.nih.gov/pubmed/35767949
http://dx.doi.org/10.1016/j.celrep.2022.111001

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