Severe inflammation in new-borns induces long-term cognitive impairment by activation of IL-1β/KCC2 signaling during early development

BACKGROUND: Neonatal sepsis can induce long-term cognitive impairment in adolescence or adulthood, but the underlying molecular mechanism is not fully understood. The expression of K(+)-Cl(–) co-transporter 2 (KCC2) plays a pivotal role in the GABAergic shift from depolarizing to hyperpolarizing dur...

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Detalles Bibliográficos
Autores principales: Zhang, Donghang, Yang, Yujiao, Yang, Yaoxin, Liu, Jin, Zhu, Tao, Huang, Han, Zhou, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327322/
https://www.ncbi.nlm.nih.gov/pubmed/35883093
http://dx.doi.org/10.1186/s12916-022-02434-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327322/
https://www.ncbi.nlm.nih.gov/pubmed/35883093
http://dx.doi.org/10.1186/s12916-022-02434-w

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