Hypoxic lung cancer cell-derived exosomal miR-21 mediates macrophage M2 polarization and promotes cancer cell proliferation through targeting IRF1

BACKGROUND: Hypoxia is the hallmark of the tumor microenvironment (TME) and plays a critical role during the progress of tumor development. A variety of microRNAs (miRNAs) transmitted by tumor-derived exosomes were involved in intercellular communication. We aimed to elucidate the precise mechanism...

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Detalles Bibliográficos
Autores principales: Jin, Jianxu, Yu, Guiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327340/
https://www.ncbi.nlm.nih.gov/pubmed/35897096
http://dx.doi.org/10.1186/s12957-022-02706-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327340/
https://www.ncbi.nlm.nih.gov/pubmed/35897096
http://dx.doi.org/10.1186/s12957-022-02706-y

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