Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner

As in neurons, CNS myelin expresses N-Methyl-D-Aspartate Receptors (NMDARs) that subserve physiological roles, but have the potential to induce injury to this vital element. Using 2-photon imaging of myelinic Ca in live ex vivo mouse optic nerves, we show that Cu ions potently modulate Ca levels in...

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Detalles Bibliográficos
Autores principales: Tsutsui, Shigeki, Morgan, Megan, Tedford, Hugo, You, Haitao, Zamponi, Gerald W., Stys, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Micro Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327403/
https://www.ncbi.nlm.nih.gov/pubmed/35883145
http://dx.doi.org/10.1186/s13041-022-00955-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327403/
https://www.ncbi.nlm.nih.gov/pubmed/35883145
http://dx.doi.org/10.1186/s13041-022-00955-2

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