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Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner

As in neurons, CNS myelin expresses N-Methyl-D-Aspartate Receptors (NMDARs) that subserve physiological roles, but have the potential to induce injury to this vital element. Using 2-photon imaging of myelinic Ca in live ex vivo mouse optic nerves, we show that Cu ions potently modulate Ca levels in...

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Detalles Bibliográficos
Autores principales:	Tsutsui, Shigeki, Morgan, Megan, Tedford, Hugo, You, Haitao, Zamponi, Gerald W., Stys, Peter K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Micro Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327403/ https://www.ncbi.nlm.nih.gov/pubmed/35883145 http://dx.doi.org/10.1186/s13041-022-00955-2

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