Influence of N-glycosylation in the A and C domains on the immunogenicity of factor VIII

The most significant complication in hemophilia A treatment is the formation of inhibitors against factor VIII (FVIII) protein. Glycans and glycan-binding proteins are central to a properly functioning immune system. This study focuses on whether glycosylation of FVIII plays an important role in ind...

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Detalles Bibliográficos
Autores principales: Vander Kooi, Amber, Wang, Shuaishuai, Fan, Meng-Ni, Chen, Alex, Zhang, Junping, Chen, Chun-Yu, Cai, Xiaohe, Konkle, Barbara A., Xiao, Weidong, Li, Lei, Miao, Carol H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327553/
https://www.ncbi.nlm.nih.gov/pubmed/35511725
http://dx.doi.org/10.1182/bloodadvances.2021005758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327553/
https://www.ncbi.nlm.nih.gov/pubmed/35511725
http://dx.doi.org/10.1182/bloodadvances.2021005758

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