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Inborn errors of immunity caused by defects in the DNA damage response pathways: Importance of minimizing treatment‐related genotoxicity
Several primary immunodeficiencies are caused by defects in the general DNA repair machinery as exemplified by the T‐B‐ radiosensitive SCID condition owing to impaired resolution of programmed DNA double‐strand breaks introduced by RAG1/2 during V(D)J recombination. The genome instability generally...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327728/ https://www.ncbi.nlm.nih.gov/pubmed/35754136 http://dx.doi.org/10.1111/pai.13820 |