First‐in‐human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist for endothelial protection

AIMS: SAR247799 is a selective G‐protein‐biased sphingosine‐1 phosphate receptor‐1 (S1P(1)) agonist with potential to restore endothelial function in vascular pathologies. SAR247799, a first‐in‐class molecule differentiated from previous S1P(1)‐desensitizing molecules developed for multiple sclerosi...

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Detalles Bibliográficos
Autores principales: Bergougnan, Luc, Armani, Sara, Golor, Georg, Tardat, Agnes, Vitse, Olivier, Hurbin, Fabrice, Scemama, Michel, Poitiers, Franck, Radzik, David, Gaudin, Christophe, Hovsepian, Lionel, Muslin, Anthony J., Kirkesseli, Stephane, Deutsch, Paul, Parkar, Ashfaq A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328431/
https://www.ncbi.nlm.nih.gov/pubmed/32520410
http://dx.doi.org/10.1111/bcp.14422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328431/
https://www.ncbi.nlm.nih.gov/pubmed/32520410
http://dx.doi.org/10.1111/bcp.14422

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