Leveraging a physiologically-based quantitative translational modeling platform for designing B cell maturation antigen-targeting bispecific T cell engagers for treatment of multiple myeloma

Bispecific T cell engagers (TCEs) are an emerging anti-cancer modality that redirects cytotoxic T cells to tumor cells expressing tumor-associated antigens (TAAs), thereby forming immune synapses to exert anti-tumor effects. Designing pharmacokinetically acceptable TCEs and optimizing their size pre...

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Detalles Bibliográficos
Autores principales: Yoneyama, Tomoki, Kim, Mi-Sook, Piatkov, Konstantin, Wang, Haiqing, Zhu, Andy Z. X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328551/
https://www.ncbi.nlm.nih.gov/pubmed/35839267
http://dx.doi.org/10.1371/journal.pcbi.1009715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328551/
https://www.ncbi.nlm.nih.gov/pubmed/35839267
http://dx.doi.org/10.1371/journal.pcbi.1009715

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