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USP5 enhances SGTA mediated protein quality control

Mislocalised membrane proteins (MLPs) present a risk to the cell due to exposed hydrophobic amino acids which cause MLPs to aggregate. Previous studies identified SGTA as a key component of the machinery that regulates the quality control of MLPs. Overexpression of SGTA promotes deubiqutination of M...

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Detalles Bibliográficos
Autores principales: Hill, Jake, Nyathi, Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328565/
https://www.ncbi.nlm.nih.gov/pubmed/35895711
http://dx.doi.org/10.1371/journal.pone.0257786