A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43

A number of neurodegenerative conditions are associated with the formation of cytosolic inclusions of TDP-43 within neurons. We expressed full-length TDP-43 in a motoneuron/neuroblastoma hybrid cell line (NSC-34) and exploited the high-resolution power of stimulated emission depletion microscopy to...

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Detalles Bibliográficos
Autores principales: Cascella, Roberta, Bigi, Alessandra, Riffert, Dylan Giorgino, Gagliani, Maria Cristina, Ermini, Emilio, Moretti, Matteo, Cortese, Katia, Cecchi, Cristina, Chiti, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328675/
https://www.ncbi.nlm.nih.gov/pubmed/35895809
http://dx.doi.org/10.1126/sciadv.abm6376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328675/
https://www.ncbi.nlm.nih.gov/pubmed/35895809
http://dx.doi.org/10.1126/sciadv.abm6376

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