SMAD4, activated by the TCR-triggered MEK/ERK signaling pathway, critically regulates CD8(+) T cell cytotoxic function

Transforming growth factor–β is well known to restrain cytotoxic T cell responses to maintain self-tolerance and to promote tumor immune evasion. In this study, we have investigated the role of SMAD4, a core component in the TGF-β signaling pathway, in CD8(+) T cells. Unexpectedly, we found that SMA...

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Detalles Bibliográficos
Autores principales: Liu, Xinwei, Hao, Jing, Wei, Peng, Zhao, Xiaohong, Lan, Qiuyan, Ni, Lu, Chen, Yongzhen, Bai, Xue, Ni, Ling, Dong, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328680/
https://www.ncbi.nlm.nih.gov/pubmed/35895826
http://dx.doi.org/10.1126/sciadv.abo4577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328680/
https://www.ncbi.nlm.nih.gov/pubmed/35895826
http://dx.doi.org/10.1126/sciadv.abo4577

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