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Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

The mTOR pathway is an essential regulator of cell growth and metabolism. Midbrain dopamine neurons are particularly sensitive to mTOR signaling status as activation or inhibition of mTOR alters their morphology and physiology. mTOR exists in two distinct multiprotein complexes termed mTORC1 and mTO...

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Detalles Bibliográficos
Autores principales: Kosillo, Polina, Ahmed, Kamran M, Aisenberg, Erin E, Karalis, Vasiliki, Roberts, Bradley M, Cragg, Stephanie J, Bateup, Helen S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328766/
https://www.ncbi.nlm.nih.gov/pubmed/35881440
http://dx.doi.org/10.7554/eLife.75398