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Water Networks Repopulate Protein–Ligand Interfaces with Temperature

High‐resolution crystal structures highlight the importance of water networks in protein–ligand interactions. However, as these are typically determined at cryogenic temperature, resulting insights may be structurally precise but not biologically accurate. By collecting 10 matched room‐temperature a...

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Detalles Bibliográficos
Autores principales: Stachowski, Timothy R., Vanarotti, Murugendra, Seetharaman, Jayaraman, Lopez, Karlo, Fischer, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329195/
https://www.ncbi.nlm.nih.gov/pubmed/35648650
http://dx.doi.org/10.1002/anie.202112919