Lactate promotes metastasis of normoxic colorectal cancer stem cells through PGC-1α-mediated oxidative phosphorylation

Uneven oxygen supply in solid tumors leads to hypoxic and normoxic regions. Hypoxic cells exhibit increased secretion of lactate, which creates an acidic tumor microenvironment (TME). This acidic TME is positively associated with tumor metastasis. Despite the increased metastatic capacity of hypoxic...

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Detalles Bibliográficos
Autores principales: Liu, Shuang, Zhao, Hui, Hu, Yibing, Yan, Chang, Mi, Yulong, Li, Xiaolan, Tao, Deding, Qin, Jichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329320/
https://www.ncbi.nlm.nih.gov/pubmed/35896535
http://dx.doi.org/10.1038/s41419-022-05111-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329320/
https://www.ncbi.nlm.nih.gov/pubmed/35896535
http://dx.doi.org/10.1038/s41419-022-05111-1

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