Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity

Identifying genetic variants associated with lower waist-to-hip ratio can reveal new therapeutic targets for abdominal obesity. We use exome sequences from 362,679 individuals to identify genes associated with waist-to-hip ratio adjusted for BMI (WHRadjBMI), a surrogate for abdominal fat that is cau...

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Detalles Bibliográficos
Autores principales: Deaton, Aimee M., Dubey, Aditi, Ward, Lucas D., Dornbos, Peter, Flannick, Jason, Yee, Elaine, Ticau, Simina, Noetzli, Leila, Parker, Margaret M., Hoffing, Rachel A., Willis, Carissa, Plekan, Mollie E., Holleman, Aaron M., Hinkle, Gregory, Fitzgerald, Kevin, Vaishnaw, Akshay K., Nioi, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329324/
https://www.ncbi.nlm.nih.gov/pubmed/35896531
http://dx.doi.org/10.1038/s41467-022-31757-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329324/
https://www.ncbi.nlm.nih.gov/pubmed/35896531
http://dx.doi.org/10.1038/s41467-022-31757-8

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