Targeting transcription in heart failure via CDK7/12/13 inhibition

Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality, highlighting an urgent need for new therapeutic strategies. As stress-activated cardiac signaling cascades converge on the nucleus to drive maladaptive gene programs, interdicting pathological transcription is a...

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Detalles Bibliográficos
Autores principales: Hsu, Austin, Duan, Qiming, Day, Daniel S., Luo, Xin, McMahon, Sarah, Huang, Yu, Feldman, Zachary B., Jiang, Zhen, Zhang, Tinghu, Liang, Yanke, Alexanian, Michael, Padmanabhan, Arun, Brown, Jonathan D., Lin, Charles Y., Gray, Nathanael S., Young, Richard A., Bruneau, Benoit G., Haldar, Saptarsi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329381/
https://www.ncbi.nlm.nih.gov/pubmed/35896549
http://dx.doi.org/10.1038/s41467-022-31541-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329381/
https://www.ncbi.nlm.nih.gov/pubmed/35896549
http://dx.doi.org/10.1038/s41467-022-31541-8

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