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Exploring and mitigating potential bias when genetic instrumental variables are associated with multiple non-exposure traits in Mendelian randomization

With the increasing size and number of genome-wide association studies, individual single nucleotide polymorphisms are increasingly found to associate with multiple traits. Many different mechanisms could result in proposed genetic IVs for an exposure of interest being associated with multiple non-e...

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Detalles Bibliográficos
Autores principales: Yang, Qian, Sanderson, Eleanor, Tilling, Kate, Borges, Maria Carolina, Lawlor, Deborah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329407/
https://www.ncbi.nlm.nih.gov/pubmed/35622304
http://dx.doi.org/10.1007/s10654-022-00874-5