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Exploring and mitigating potential bias when genetic instrumental variables are associated with multiple non-exposure traits in Mendelian randomization
With the increasing size and number of genome-wide association studies, individual single nucleotide polymorphisms are increasingly found to associate with multiple traits. Many different mechanisms could result in proposed genetic IVs for an exposure of interest being associated with multiple non-e...
Autores principales: | Yang, Qian, Sanderson, Eleanor, Tilling, Kate, Borges, Maria Carolina, Lawlor, Deborah A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329407/ https://www.ncbi.nlm.nih.gov/pubmed/35622304 http://dx.doi.org/10.1007/s10654-022-00874-5 |
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